Expression of FOXP3 and TGF-β_1 in Human Villi of Patients with Recurrent Spontaneous Abortion

Objective:To observe the expression of FOXP3 and TGF-β1 in human villi of patients with recurrent spontaneous abortion(RSA).Methods:Expression and distribution of FOXP3 and TGF-β1 were observed in 20 cases of patients with RSA and 20 cases of normal early pregnant women(controls) by immunohistochemistry.Results:The expression of FOXP3 and TGF-β1 was observed in both study objects,it was mainly expressed in endochylema of syneytiotrophoblast.The expression in patients with RSA was lower significantly than that in controls(P0.01).The expression of FOXP3 and TGF-β1 in RSA patients had no obvious correlation.Conclusion:The lower expression of FOXP3 and TGF-β1 in human villi may be invovled in the pathogenesis of RSA.