A Comparison of Overall Survival between Definitive Local Therapy and Systemic Therapy in Metastatic Sinonasal Malignancies

Objectives: For patients presenting with metastatic sinonasal neoplasms, systemic chemotherapy usually underpins the standard of care. Emerging evidence has shown that primary tumor resection or ablation may improve overall survival in other metastatic malignancies, including those located at various head and neck subsites. The primary objective of this study is to determine if definitive local therapy improves overall survival in metastatic sinonasal malignancies.