立体中心
奎尼嗪
化学
槐花
苦参碱
圆二色性
量子化学
体内
绝对构型
环加成
立体化学
分子
有机化学
生物
生物碱
催化作用
对映选择合成
中医药
替代医学
生物技术
病理
医学
色谱法
作者
Xiang Yuan,Jian‐Shuang Jiang,Yanan Yang,Xu Zhang,Zi‐Ming Feng,Pei‐Cheng Zhang
标识
DOI:10.1016/j.cclet.2021.10.085
摘要
Sophoralines A–C, three novel [2 + 2] cycloaddition dimers of matrine-based alkaloids with an unprecedented 6/6/6/6/4/6/6/6/6 nonacyclic skeleton containing 11 stereogenic centers, were isolated from Sophora alopecuroides. Their structures were determined by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemical calculations of electronic circular dichroism (ECD) spectra for 2 and 3. Moreover, 1 exhibited excellent hepatoprotective activities in acetaminophen-induced liver injury in vitro and in vivo.
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