化学
吡啶
碘化物
盐(化学)
碘甲烷
胺气处理
甲基化
有机化学
组合化学
表面改性
功能群
还原消去
分子
烷基
催化作用
聚合物
物理化学
基因
生物化学
作者
Olivia P. Bercher,Shane Plunkett,Thomas E. Mortimer,Mary P. Watson
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-31
卷期号:23 (18): 7059-7063
被引量:14
标识
DOI:10.1021/acs.orglett.1c02458
摘要
Methyl groups can imbue valuable properties in organic molecules, often leading to enhanced bioactivity. To enable efficient installation of methyl groups on simple building blocks and in late-stage functionalization, a nickel-catalyzed reductive coupling of secondary Katritzky alkylpyridinium salts with methyl iodide was developed. When coupled with formation of the pyridinium salt from an alkyl amine, this method allows amino groups to be readily transformed to methyl groups with broad functional group and heterocycle tolerance.
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