间充质干细胞
微泡
心功能曲线
移植
医学
心脏纤维化
心肌梗塞
体内
纤维化
再生医学
癌症研究
干细胞
病理
心脏病学
内科学
细胞生物学
生物
心力衰竭
小RNA
生物技术
生物化学
基因
作者
Shuo Wang,Liu Li,Tao Liu,Wenyan Jiang,Xitian Hu
出处
期刊:Regenerative Medicine
[Future Medicine]
日期:2020-06-01
卷期号:15 (6): 1749-1759
被引量:28
标识
DOI:10.2217/rme-2019-0136
摘要
Aim: We aimed to investigate the protection of exogenous miR-19a/19b with bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation on cardiac function and inhibition of fibrosis in myocardial infarction (MI). Materials & methods: BM-MSC-derived exosomes were used to deliver miR-19a/19b (exo/miR-19a/19b) to the cultured cardiac HL-1 cells, and the apoptosis of cells were evaluated. Exo/miR-19a/19b and BM-MSCs were also transplanted to an in vivo MI mouse model. The recovery of cardiac function was assessed and the level of cardiac fibrosis was determined. Results: Exo/miR-19a/19b and MSCs reduced the area of cardiac fibrosis in the heart tissue in the mouse MI model. Using BM-MSC-derived exosomes as a vehicle, miR-19a/19b significantly suppressed the apoptosis of cardiac HL-1 cells. The combination of Exo/miR-19a/19b and MSC transplantation significantly enhanced the recovery of cardiac function and reduced cardiac fibrosis in the MI model. Conclusion: Our study provides an effective regenerative intervention strategy to attenuate the damage of MI.
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