丝素
丝绸
材料科学
生物电子学
甲基丙烯酸酯
高分子科学
聚合物
纳米技术
生物相容性材料
微加工
聚合
高分子化学
作者
Xuan Mu,Jugal Kishore Sahoo,Peggy Cebe,David L. Kaplan
出处
期刊:Polymers
[MDPI AG]
日期:2020-12-09
卷期号:12 (12): 2936-2936
被引量:15
标识
DOI:10.3390/polym12122936
摘要
Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future.
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