肿瘤坏死因子α
癌症研究
关节炎
白细胞介素
分子医学
细胞因子
内科学
癌基因
生物
白细胞介素6
药理学
作者
Xi-feng Zhang,Ying Zou,Jiangxia Zheng,Sen-guo Ji,Xiuzhen Wen,Feng Ye,Ju Liu,Xueyong Li,Jin Lei,Mingliang Qiu
出处
期刊:Molecular Medicine Reports
[Spandidos Publications]
日期:2020-09-01
卷期号:22 (3): 2227-2234
被引量:2
标识
DOI:10.3892/mmr.2020.11314
摘要
Acute gouty arthritis (AGA) is characterized by the accumulation of pro-inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non-coding RNA (lncRNA)-MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA-MM2P regulates the MSU-induced inflammatory process. In cell models of RAW 264.7 and THP-1-derived macrophages, decreased expression of lncRNA-MM2P was observed in lipopolysaccharide- and MSU-treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA-MM2P led to the upregulation of MSU-mediated inflammatory responses, both in RAW 264.7 and THP-1-derived macrophages. In conclusion, lncRNA-MM2P could be an important regulator of MSU-induced inflammation, and therefore could be involved in the development of AGA.
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