氧化应激
半影
纳米团簇
缺血
神经保护
活性氧
医学
药理学
麻醉
化学
材料科学
内科学
纳米技术
生物化学
作者
Shiyong Li,Dawei Jiang,Emily B. Ehlerding,Zachary T. Rosenkrans,Jonathan W. Engle,Ye Wang,Huisheng Liu,Dalong Ni,Weibo Cai
出处
期刊:ACS Nano
[American Chemical Society]
日期:2019-10-11
卷期号:13 (11): 13382-13389
被引量:52
标识
DOI:10.1021/acsnano.9b06780
摘要
Oxidative stress is one of the important mechanisms in cerebral ischemia/reperfusion (I/R) injury. Antioxidants with high brain accumulation are highly desired to help prevent cerebral I/R injury. Herein, intrathecal injection of polyoxometalate (POM) nanoclusters as nano-antioxidants with preferential brain uptake were applied for neuronal protection in cerebral I/R injury. Using powerful positron emission tomography imaging, the uptake of nano-antioxidants in the brain was non-invasively and real-timely monitored. Our results demonstrated that POM nanoclusters rapidly reached the ischemic penumbra after intrathecal injection and effectively scavenged reactive oxygen species (ROS) for inhibiting oxidative stress. The infarct size was reduced, and neurological function was restored in cerebral I/R injury rat models. As a proof-of-concept, the intrathecal injection of nano-antioxidants is an excellent therapeutic strategy to ameliorate cerebral I/R injury.
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