Possibility of prostaglandins and their analogues in the treatment and prevention of cerebral small vessel diseases

Cerebral small vessel disease (CSVD) is a group of syndromes involving cerebral microcirculation. The clinical manifestations include stroke, dementia, abnormal gait, and urination disorders, etc. There is currently no effective treatment option. Prostaglandins and their analogues exert multiple effects such as dilating blood vessels, inhibiting platelet aggregation, protecting endothelium, and improving microcirculation by activating specific receptors. They may have a certain effect on the CSBD. This article reviews the possibility of prostaglandins and their analogues in the treatment and prevention of CSVD. Key words: Cerebral small vessel diseases; Prostaglandins; Receptors, prostaglandin