有机催化
级联反应
药物化学
组合化学
迈克尔反应
双功能
对映选择合成
作者
Tsung-Jung Jao,Pavan Sudheer Akula,Bor-Cherng Hong,Gene-Hsiang Lee
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-01-03
卷期号:22 (1): 62-67
被引量:2
标识
DOI:10.1021/acs.orglett.9b03912
摘要
New types of organocatalytic 1,2-rearrangements, which resemble the Smiles-like or semi-pinacol-like rearrangement, of Michael adducts of 1,3-dicarbonyl-2-alkyl compounds and nitroalkenes have been realized. Unlike the well-known conjugate addition, the reaction affords the 1-phenyl-1-nitroalkanes via unprecedented rearrangement and cascade reactions. Structures of the appropriate products were unambiguously characterized by X-ray crystallography.
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