Phytochemical Analysis and Antioxidant Property of Rhizome extracts aqueous of Phragmites australis in Alloxan Diabetic Rats

The present study was aimed to investigate the effect of phragmites australis aqueous extracts on lipid peroxidation and antioxidant status in some tissues of alloxan induced diabetic rats. In our experiment study, rats were divided into three groups of five animals in each; Control, diabetic and diabetic + 200 mg/kg extract plant groups. All rats except those in the control group were made diabetic using a single intraperitoneal injection of 150 mg/kg alloxan. Administration of extract began four days after induction of diabetes and lasted for three weeks. The results of the phytochemical analysis revealed that Total phenol and flavonoid content in P. Australis aqueous extract shows highest concentration in aqueous extract of P. australis (34.10mg GA EQ/gm, 3.27mg QEQ/gm). contained various bioactive compounds, including tanin, terpenoids, glycosides and flavonoids. Administration of (200mg/kg body weight/day) extracts in diabetic rats has remarkably improved the elevated levels of fasting blood glucose, triglyceride and LDL concentration. A significant decrease in lipid peroxidation (p<0.001) and small increase in the reduced glutathione (GSH) contents in kidney tissue of diabetic rats were observed. Our studies demonstrate the anti-hyperglycemic and anti-oxidative potential of phragmites australis, which could exert beneficial effects against the diabetes and associated free radicals complications in kidney tissue.