粒体自噬
医学
心肌梗塞
心脏病学
疾病
心力衰竭
发病机制
内科学
心肌病
心功能曲线
线粒体
机制(生物学)
自噬
生物
细胞生物学
细胞凋亡
哲学
认识论
生物化学
作者
Hong Zhou,Lu He,Gaolian Xu,Linxi Chen
标识
DOI:10.1016/j.cca.2020.04.033
摘要
Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide. Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD, such as atherosclerosis (AS), hypertension, myocardial ischemia-reperfusion (MI/R) injury, myocardial infarction (MI), cardiac hypertrophy, heart failure (HF), dilated cardiomyopathy (DCM) and so on. Mitophagy is a mitochondrial quality control mechanism that eliminates damaged or superfluous mitochondria to maintain cardiac function in response to various stress and cardiac disease conditions. This article reviews the latest findings regarding the mechanistic, functional, and potential role of mitophagy in the pathogenesis of CVD. Moreover, various drugs can target mitophagy activity during CVD progression. Thus, the modulation of the mitophagy pathway provides a potential therapeutic strategy for CVD management.
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