碘化油
免疫系统
聚乙二醇
癌症研究
生物物理学
医学
化学
生物医学工程
免疫学
生物化学
生物
肝细胞癌
作者
Fei Gong,Jiachen Xu,Bo Liu,Nailin Yang,Liang Cheng,Peng Huang,Chunjie Wang,Qian Chen,Ni Chen,Zhuang Liu
出处
期刊:Chem
[Elsevier]
日期:2022-01-01
卷期号:8 (1): 268-286
被引量:59
标识
DOI:10.1016/j.chempr.2021.11.020
摘要
Herein, we prepared CaH2 nanoparticles through liquid-phase exfoliation and first applied them as an antitumor therapeutic agent. Being dispersed in low-molecular-weight polyethylene glycol (PEG) and injected into the tumor, nano-CaH2 would react with water to generate abundant hydrogen gas (H2), calcium ions (Ca2+), and hydroxyl ions (OH−), enabling hydrogen therapy, tumor calcification, and neutralization of acidic tumor microenvironment (TME), respectively. The injectable nano-CaH2 dispersion could lead to significant tumor growth inhibition. In addition, the local nano-CaH2-induced tumor cell apoptosis and TME modulation would activate the immune system and promote tumor infiltration of immune cells, which, working together with immune checkpoint blockade, could elicit robust immune responses to inhibit abscopal distant tumors without direct nano-CaH2 injection. Furthermore, nano-CaH2 could be dispersed in lipiodol to obtain CaH2-lipiodol dispersion for interventional transarterial embolization (TAE) therapy, and they showed obviously improved TAE therapeutic outcome on orthotopic rabbit liver cancer model compared with lipiodol alone.
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