基底外侧杏仁核
扁桃形结构
心理学
焦虑
睡眠剥夺
恐惧条件反射
大脑中的恐惧处理
神经科学
听力学
神经影像学
意识的神经相关物
医学
精神科
认知
作者
Pan Feng,Benjamin Becker,Feng Zhou,Tingyong Feng,Zhiyi Chen
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2022-06-14
卷期号:33 (6): 2655-2668
标识
DOI:10.1093/cercor/bhac233
摘要
Sleep deprivation (SD) may lead to the development of fear- and anxiety-related emotional disorders. However, the neural mechanisms underlying the effects of SD on fear acquisition are unclear. Here, we tested whether and how SD influences the behavioral and neural manifestations of fear acquisition. We found that subjective fear ratings and objective fear indices (skin conductance response [SCR]) in the SD group were greater than those in the control group during fear acquisition, suggesting that SD facilitated fear acquisition (nSD = 18 and ncontrol = 23 for self-reported rating analysis; nSD = 10 and ncontrol = 10 for SCR analysis). Neuroimaging data showed that the SD group exhibited stronger activity in the left basolateral amygdala (BLA) and left superficial amygdala (SFA). Moreover, the left BLA activity, which positively correlated with the objective fear indices, significantly mediated the effect of SD on fear acquisition. Together, the present findings indicate that SD facilitates fear acquisition by augmenting threat-specific encoding in the BLA, which may be a potential biomarker of the risk of developing fear-related disorders under traumatic and distressing situations.
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