拉布
GTP酶
细胞生物学
自噬
小型GTPase
生物
疾病
细胞内
囊泡转运蛋白
小泡
医学
信号转导
遗传学
膜
内科学
细胞凋亡
作者
Jiayi Liu,Xuanjun Zheng,Xiaoqian Wu
出处
期刊:Life Sciences
[Elsevier]
日期:2022-10-01
卷期号:306: 120806-120806
被引量:3
标识
DOI:10.1016/j.lfs.2022.120806
摘要
Rab proteins are a family of small GTPases that function as molecular switches of intracellular vesicle formation and membrane trafficking. As a key factor, Rab GTPase participates in autophagy and protein transport and acts as the central hub of membrane trafficking in eukaryotes. The role of Rab GTPase in neurodegenerative disorders, such as Alzheimer's and Parkinson's, has been extensively investigated; however, its implication in cardiovascular embryogenesis and diseases remains largely unknown. In this review, we summarize previous findings and reveal their importance in the onset and progression of cardiac diseases, as well as their emergence as potential therapeutic targets for cardiovascular disease.
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