Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

Postulated mechanisms of lifespan extension by EGT: preservation of CNS via the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulated autophagic activity, and preservation of mitochondrial function.