A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors

In this work, a pendant droplet-based sensor is developed for the rapid and label-free detection of acetylcholinesterase (AChE) and its inhibitors. The detection limit of AChE reaches 0.17 mU mL-1. The pIC50 values of AChE inhibitors such as neostigmine, rivastigmine and galantamine are determined to be 0.45 μM, 0.64 μM and 4.93 μM, respectively.