表阿霉素
医学
紫杉醇
转移
透明质酸
乳腺癌
毒性
化疗
细胞凋亡
癌症研究
体内
肿瘤科
内科学
体外
药理学
癌症
化学
生物
解剖
生物技术
生物化学
作者
Qingqing Leng,Yue Li,Ping Zhou,Kang Xiong,Yun Lü,Yongxia Cui,Biqiong Wang,Zhi‐Ying Wu,Ling Zhao,Shaozhi Fu
标识
DOI:10.1016/j.msec.2021.112390
摘要
Post-operative recurrence and metastasis is a major challenge for breast cancer treatment. Local chemotherapy is a promising strategy that can overcome this problem. In this study, we synthesized an injectable hyaluronic acid (HA)-based hydrogel loaded with paclitaxel (PTX) nanoparticles and epirubicin (EPB) (PPNPs/[email protected]). PPNPs/[email protected] steadily released the encapsulated drugs to achieve long-term inhibition of tumor recurrence and metastasis in a murine post-operative breast tumor model, which prolonged their survival without any systemic toxicity. The drug-loaded hydrogel inhibited the proliferation and migration of tumor cells in vitro, and significantly increased tumor cell apoptosis in vivo. Therefore, PPNPs/[email protected] can be used as a local chemotherapeutic agent to prevent postoperative recurrence and metastasis of breast cancer.
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