自噬
细胞生物学
化学
癌症研究
细胞内
内体
PI3K/AKT/mTOR通路
程序性细胞死亡
内吞作用
TFEB
生物
溶酶体
作者
Gourish Mondal,Jayanta Debnath
出处
期刊:Cancer Cell
[Elsevier]
日期:2021-05-10
卷期号:39 (5): 596-598
标识
DOI:10.1016/j.ccell.2021.03.011
摘要
Su et al. demonstrate that upon inhibiting autophagy, an intracellular nutrient recycling pathway, pancreatic ductal adenocarcinoma cells upregulate NRF2-mediated transcription of macropinocytosis pathway components, thereby triggering an alternate route for tumors to scavenge nutrients from extracellular sources. Accordingly, the combined inhibition of autophagy and macropinocytosis may improve cancer treatment.
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