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Glycoproteomic Bioanalysis of Exosomes by LC–MS for Early Diagnosis of Pancreatic Cancer

中国 药店 图书馆学 传统医学 医学 家庭医学 政治学 计算机科学 法学
作者
Mingming Xu,Wenhua Hu,Zhaoliang Liu,Jun Xia,Sufeng Chen,Perry G. Wang,Shuang Yang
出处
期刊:Bioanalysis [Future Science Ltd]
卷期号:13 (11): 861-864 被引量:16
标识
DOI:10.4155/bio-2021-0036
摘要

BioanalysisVol. 13, No. 11 EditorialGlycoproteomic bioanalysis of exosomes by LC–MS for early diagnosis of pancreatic cancerMingming Xu, Wenhua Hu, Zhaoliang Liu, Jun Xia, Sufeng Chen, Perry G Wang & Shuang YangMingming Xu https://orcid.org/0000-0002-8158-2879Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, PR China, Wenhua Hu https://orcid.org/0000-0002-0471-3652Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, PR China, Zhaoliang Liu https://orcid.org/0000-0002-7267-9118Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, PR China, Jun Xia https://orcid.org/0000-0003-3222-2882Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, PR China, Sufeng Chen https://orcid.org/0000-0002-8780-5658Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, PR China, Perry G Wang **Author for correspondence: E-mail Address: wanggperry@gmail.comhttps://orcid.org/0000-0003-3656-824XCenter for Food Safety & Applied Nutrition, US Food & Drug Administration, College Park, MD 20740, USA & Shuang Yang *Author for correspondence: E-mail Address: yangs2020@suda.edu.cnhttps://orcid.org/0000-0001-7958-0594Center for Clinical Mass Spectrometry, School of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, PR ChinaPublished Online:18 May 2021https://doi.org/10.4155/bio-2021-0036AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: biomarkerearly diagnosisexosomeglycosylationmass spectrometrypancreatic cancerReferences1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68(6), 394–424 (2018).Crossref, Medline, Google Scholar2. Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N. Engl. J. Med. 371(11), 1039–1049 (2014).Crossref, Medline, CAS, Google Scholar3. Kalthoff H, Kreiker C, Schmiegel WH, Greten H, Thiele HG. Characterization of CA 19-9 bearing mucins as physiological exocrine pancreatic secretion products. Cancer Res. 46(7), 3605–3607 (1986).Medline, CAS, Google Scholar4. Remmers N, Anderson JM, Linde EM et al. Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. Clin. Cancer Res. 19(8), 1981–1993 (2013).Crossref, Medline, CAS, Google Scholar5. Park HM, Hwang MP, Kim YW et al. Mass spectrometry-based N-linked glycomic profiling as a means for tracking pancreatic cancer metastasis. Carbohydr. Res. 413, 5–11 (2015).Crossref, Medline, CAS, Google Scholar6. Qian K, Wang S, Fu M et al. Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. J. Biol. Chem. 293(36), 13989–14000 (2018).Crossref, Medline, CAS, Google Scholar7. Yang S, Xia J, Yang Z, Xu M, Li S. Lung cancer molecular mutations and abnormal glycosylation as biomarkers for early diagnosis. Cancer Treat. Res. Commun. 27, 100311 (2021).Crossref, Medline, Google Scholar8. Erozenci LA, Bottger F, Bijnsdorp IV, Jimenez CR. Urinary exosomal proteins as (pan-)cancer biomarkers: insights from the proteome. FEBS Lett. 593(13), 1580–1597 (2019).Crossref, Medline, CAS, Google Scholar9. Wang YT, Shi T, Srivastava S, Kagan J, Liu T, Rodland KD. Proteomic analysis of exosomes for discovery of protein biomarkers for prostate and bladder cancer. Cancers (Basel) 12(9), 2335 (2020).Crossref, CAS, Google Scholar10. Melo SA, Luecke LB, Kahlert C et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523(7559), 177–182 (2015).Crossref, Medline, CAS, Google Scholar11. Hildonen S, Skarpen E, Halvorsen TG, Reubsaet L. Isolation and mass spectrometry analysis of urinary extraexosomal proteins. Sci. Rep. 6(1) (2016).Crossref, Medline, Google Scholar12. Ohkuma R, Yada E, Ishikawa S et al. High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer. PLoS ONE 15(1), e0226707 (2020).Crossref, Medline, CAS, Google Scholar13. Yang S, Onigman P, Wu WW et al. Deciphering protein O-glycosylation: solid-phase chemoenzymatic cleavage and enrichment. Anal. Chem. 90(13), 8261–8269 (2018).Crossref, Medline, CAS, Google Scholar14. Yang S, Li Y, Shah P, Zhang H. Glycomic analysis using glycoprotein immobilization for glycan extraction. Anal. Chem. 85(11), 5555–5561 (2013).Crossref, Medline, CAS, Google Scholar15. Hahne H, Neubert P, Kuhn K et al. Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans. Anal. Chem. 84(8), 3716–3724 (2012).Crossref, Medline, CAS, Google Scholar16. Ye H, Boyne MT 2nd, Buhse LF, Hill J. Direct approach for qualitative and quantitative characterization of glycoproteins using tandem mass tags and an LTQ Orbitrap XL electron transfer dissociation hybrid mass spectrometer. Anal. Chem. 85(3), 1531–1539 (2013).Crossref, Medline, CAS, Google Scholar17. Yang S, Yuan W, Yang W et al. Glycan analysis by isobaric aldehyde reactive tags and mass spectrometry. Anal. Chem. 85(17), 8188–8195 (2013).Crossref, Medline, CAS, Google Scholar18. Yang S, Wang M, Chen L et al. QUANTITY: an isobaric tag for quantitative glycomics. Sci. Rep. 5, 17585 (2015).Crossref, Medline, CAS, Google Scholar19. An M, Lohse I, Tan Z et al. Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy. J. Proteome Res. 16(4), 1763–1772 (2017).Crossref, Medline, CAS, Google Scholar20. Tao S, Huang Y, Boyes BE, Orlando R. Liquid chromatography-selected reaction monitoring (LC–SRM) approach for the separation and quantitation of sialylated N-glycans linkage isomers. Anal. Chem. 86(21), 10584–10590 (2014).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByTechnique development of high-throughput and high-sensitivity sample preparation and separation for proteomicsZhenbin Zhang, Minyang Zheng, Yufen Zhao & Perry G Wang2 December 2021 | Bioanalysis, Vol. 14, No. 2 Vol. 13, No. 11 Follow us on social media for the latest updates Metrics Downloaded 206 times History Received 27 February 2021 Accepted 22 April 2021 Published online 18 May 2021 Published in print June 2021 Information© 2021 Newlands PressKeywordsbiomarkerearly diagnosisexosomeglycosylationmass spectrometrypancreatic cancerDisclaimerPG Wang co-authors this paper in his own capacity but not as an employee of the US FDA. The views expressed in the article are the employee's and do not represent the government.Financial & competing interests disclosureThis work was supported by Soochow University Start-up fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
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