The discovery of penicillin in the late 1920s started a new epoch of chemical therapeutics by antibiotics. Ever since then,many infective diseases have been effectively controlled. Consequently,the research,exploitation and utilization of many kinds of antibiotics develop very quickly. The development,research and manufacturing of antibiotics undergo three stages:natural antibiotics,semisynthetic antibiotics and pharmacologic active substance. According to the feature of its chemical structure,antibiotics can be grouped into five categories: #beta#-Lactam Antibiotics,Aminoglycoside Antibiotics, Macrolide Antibiotics, Tetracycline Antibiotics,and Antineoplastic Antibiotics.