富血小板血浆
生物医学工程
脚手架
股骨髁
再生(生物学)
间充质干细胞
磷酸钙骨水泥
血小板
钙
化学
医学
骨髓
病理
解剖
细胞生物学
内科学
生物
软骨
作者
Guangjun Li,Wenai Shen,Xing Tang,Guowei Mo,Liqin Yao,Jixing Wang
出处
期刊:Regenerative Medicine
[Future Medicine]
日期:2021-05-01
卷期号:16 (5): 451-464
被引量:2
标识
DOI:10.2217/rme-2020-0099
摘要
Aim: To investigate the outcome of autologous bone marrow mesenchymal stem cells (BMMSCs) and platelet-rich plasma in combination with calcium phosphate cement (CPC) scaffold to reconstruct femoral critical bone defects in mini-pigs. Materials & methods: Scanning electron microscopy, micro-computed tomography evaluation and quantitative histological assessment were used. Results & conclusion: BMMSCs were attached to the CPC scaffold after 7 days of culture and decreased the residual CPC material in each group at 12 weeks compared with 6 weeks. The newly formed bone area was higher in the CPC+SC+P group than in the CPC group at each time point (all p < 0.05). The strategy of CPC combined with BMMSCs and platelet-rich plasma might be an effective method to repair bone defects.
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