材料科学
光热治疗
纳米颗粒
生物相容性
磁共振成像
体内
核磁共振
纳米技术
生物物理学
生物技术
医学
物理
放射科
冶金
生物
作者
Rui Ge,Min Lin,Xing Li,Shuwei Liu,Wenjing Wang,Shuyao Li,Xue Zhang,Yi Liu,Lidi Liu,Feng Shi,Hongchen Sun,Hao Zhang,Bai Yang
标识
DOI:10.1021/acsami.7b05583
摘要
Cancer multimodal treatment by combining the effects of different theranostics agents can efficiently improve treatment efficacy and reduce side effects. In this work, we demonstrate the theranostics nanodevices on the basis of Cu2+-loaded polydopamine nanoparticles (CuPDA NPs), which are able to offer magnetic resonance imaging (MRI)-guided thermochemotherapy (TCT). Systematical studies reveal that after Cu2+ ions loading, the molar extinction coefficient of PDA NPs is greatly enhanced by 4 times, thus improving the performance in photothermal therapy. Despite Cu2+ ions being toxic, the release of Cu2+ is mainly stimulated in acidic environment. Once the NPs deposit in the slightly acidic tumor microenvironment (pH ≈ 6.5–6.8), the release rate boosts ∼30%, which effectively avoids the systematic toxicity during chemotherapy. Meanwhile, due to the increment of the electron–proton dipole–dipole interaction correlation time τC, the spin–lattice relaxation time (T1) for PDA NPs is found to be shortened by Cu2+ loading, which boosts the longitudinal relaxivity (r1). Hence, CuPDA NPs can be used as T1-weighted contrast agent in MRI. In addition, due to the naturally existing DA in the human body with stealth effect, CuPDA NPs have an outstanding tumor retention rate as high as 8.2% ID/g. Further in vitro and in vivo tests indicate that CuPDA NPs possess long blood circulation time, good photothermal and physiological stability, and biocompatibility, which are potential nanodevices for MRI-guided TCT with minimal side effects.
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