室管膜细胞
生物
水通道蛋白
水通道蛋白4
流出
细胞生物学
神经科学
解剖
中枢神经系统
生物化学
作者
Gry Fluge Vindedal,Anna E. Thoren,Vidar R. Jensen,Arne Klungland,Yong Zhang,Michael J. Holtzman,Ole Petter Ottersen,Erlend A. Nagelhus
标识
DOI:10.1016/j.mcn.2016.10.004
摘要
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4-/- mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice). Unique for the global Aqp4-/- mice is the loss of the AQP4 pool subjacent to the pial membrane. Our data suggest that water accumulates in brain when subpial AQP4 is missing, pointing to a critical role of this pool of water channels in brain water exit.
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