Synthesis and Crystal Structure of [a-(2,4-Difluorophenyl)-a-(1H-1,2,4- triazole-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol]Cu(II) Complex

INTRODUCTIONFluconazole [α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazole-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol] is a triazole antifungal agent which is used in the treatment and prevention of superficial and systemic fungal infections 1-5 such as or Opharyngeal candidiasis and Cryptococcal meningitis in AIDS.Fluconazole can inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms.In addition, it may also inhibit purine uptake and impair triglyceride and/or phospholipid biosynthesis.This compound belongs to the phenylpropylamines containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.In order to improve the bioavailability or treatment effect and develop new applications for fluconazole, metal complex of it has been extensively investigated in our group.In this paper, as a contribution in this filed, we report here the crystal structure of the complex of fluconazole with copper. EXPERIMENTAL Determination of crystal structure:The crystal of title compound with dimensions of 0.48 mm × 0.42 mm × 0.40 mm was mounted on a Rigaku Saturn CCD area-detector diffractometer with a graphite-monochromated MoKα radiation (λ = 0.71073 Å) by using a phi and scan modes at 298 K in the range of 2.1º ≤ θ ≤ 25º.The crystal belongs to monoclinic system with space group C2/c and crystal parameters of a = 23.490(2),b = 9.4719(9), c = 19.8459(18) Å, α = 90.00,β = Synthesis and Crystal Structure of [α α α α α-(2,4-Difluorophenyl)-α α α α α-(1H-1,2,4triazole-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol]Cu(II) Complex