氧化应激
化学
纹状体
脂质过氧化
槲皮素
内分泌学
谷胱甘肽
内科学
前额叶皮质
海马体
睡眠剥夺
抗氧化剂
药理学
心理学
生物化学
神经科学
医学
昼夜节律
多巴胺
酶
认知
作者
Luiz Kae Sales Kanazawa,Débora Dalla Vecchia,Etiéli Mara Wendler,Palloma de Almeida Soares Hocayen,Francislaine Aparecida dos Reis Lívero,Maria Carolina Stipp,Inara M.R. Barcaro,Alexandra Acco,Roberto Andreatini
标识
DOI:10.1016/j.freeradbiomed.2016.07.027
摘要
Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative stress were induced by 24 h paradoxical sleep deprivation (PSD) in male Swiss mice. Both 10 and 40 mg/kg quercetin prevented PSD-induced hyperlocomotion. Quercetin reversed the PSD-induced decrease in glutathione (GSH) levels in the prefrontal cortex (PFC) and striatum. Quercetin also reversed the PSD-induced increase in lipid peroxidation (LPO) in the PFC, hippocampus, and striatum. Pearson's correlation analysis revealed a negative correlation between locomotor activity and GSH in the PFC in sleep-deprived mice and a positive correlation between locomotor activity and LPO in the PFC and striatum in sleep-deprived mice. These results suggest that quercetin exerts an antimanic-like effect at doses that do not impair spontaneous locomotor activity, and the antioxidant action of quercetin might contribute to its antimanic-like effects.
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