Cu/Ag‐Cocatalyzed Aerobic Oxidative Amination and CuCl2‐Mediated Aerobic Oxidative Chloroamination of Maleimides

An efficient Cu(OAc) 2 /Ag 2 CO 3 ‐cocatalyzed approach for the synthesis of 3‐aminomaleimides and 3‐amino‐4‐indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl 2 leads to the formation of chloroamination products such as 3‐amino‐4‐chloromaleimides by a radical‐type mechanism.