Total Synthesis of Atorvastatin

Atorvastatin calcium (HMG-CoA reductase inhibitor) is the most widely used cholesterol lowering drugs. Its synthesis has attracted broad attention of synthetic chemistry community. In this study, a new strategy has been developed toward the synthesis of atorvastatin in 13 steps and 9% overall yield. Keywords atorvastatin calcium; cholesterol lowering drug; organic synthesis ( ). , 1500 [1] , . , , (TC) . 70% TC , , . , , . , (Atorvastatin Calcium)(Lipitor), (3R,5R)-7-[2-(4-)-3--4-()-5-(2-)-1-]-3,5-( 1), . , , 3--3- A (HMG-CoA reductase), . 1 Figure 1 Structure of atorvastatin calcium