抗生素
抗生素耐药性
群体感应
生物膜
微生物群
自然(考古学)
广谱
化学
致病菌
微生物学
生化工程
纳米技术
计算生物学
细菌
生物
组合化学
生物信息学
遗传学
工程类
材料科学
古生物学
作者
Sean E. Rossiter,Madison H. Fletcher,William M. Wuest
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2017-09-27
卷期号:117 (19): 12415-12474
被引量:382
标识
DOI:10.1021/acs.chemrev.7b00283
摘要
Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.
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