金属化
对映选择合成
催化作用
化学
氢键
过渡金属
有机合成
配体(生物化学)
立体化学
组合化学
分子
有机化学
生物化学
受体
作者
Tyler G. Saint‐Denis,Ru‐Yi Zhu,Gang Chen,Qing‐Feng Wu,Jin‐Quan Yu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-02-16
卷期号:359 (6377)
被引量:608
标识
DOI:10.1126/science.aao4798
摘要
Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C-H bonds to new functionalities (such as C-C, C-N, and C-O bonds) has garnered much attention by the synthetic chemistry community. The utility of C-H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C-H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp3)-H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp3)-H bonds and stereomodels for asymmetric metalation of prochiral C-H bonds by these catalysts.
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