Nanomedicine is the application of nanobiotechnology to clinical medicine. However, new technologies do not always enter medical practice directly. Nanobiotechnologies are being used to research the pathomechanism of disease, refine molecular diagnostics, and help in the discovery, development, and delivery of drugs. In some cases, nanoparticles are the nanomedicines. The role is not confined to drugs before devices, and surgical procedures are refined by nanobiotechnology, referred to as nanosurgery.