祖细胞
胰岛素抵抗
2型糖尿病
基质凝胶
内皮干细胞
糖尿病
人口
骨髓
血管生成
医学
内分泌学
生物
内科学
干细胞
细胞生物学
免疫学
血管生成
体外
生物化学
环境卫生
作者
Jerzy Kotlinowski,Józef Dulak,Alicja Józkowicz
出处
期刊:PubMed
日期:2013-01-01
卷期号:59 (3): 257-66
被引量:5
摘要
Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by insulin resistance that leads to changes in glucose metabolism. Importantly, both insulin resistance and hyperglycemia are present in T2DM patients as a hallmarks of metabolic syndrome. They negatively affect functions of many cells, for example endothelial cells. Endothelial progenitor cells (EPC) is a population of mononuclear cells that expresses endothelial and progenitor markers. EPC are also characterized by ability to form tubes on matrigel, outgrowth into mature endothelial cells, produce proangiogenic factors or take part in the blood vessels formation. Upon injury endothelial progenitor cells are mobilized from bone marrow, home to injured site and take part in vessels formation. It was shown however, that functions of EPC in T2DM patients are impaired. In this review we focused on the T2DM and its detrimental effects on EPC biology. taking also into account the beneficiary role of anti-diabetic drugs. Decreased number and impaired functions of EPC in T2DM patients might lead to increased frequency of cardiovascular incidents and development of micro- or macroangiopathies.
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