A natural substance that acts to control plant activities are Plant growth regulators and often called phytohormones to regulate growth, development and responses to stimuli. Which includes hormones and non-nutrient chemicals not found naturally in plants that when applied in plants, influence their growth and development. Changes in phytohormone levels result in gene activation shifts. This paper accomplishes the review article on chemistry of the novel plant growth regulators according to their medications, and has been discussed according to the types of plant growth regulators.