Network dysfunction after traumatic brain injury

The clinical effects of focal brain damage have been researched extensively, but the consequences of diffuse axonal injuries are less well described. Advanced neuroimaging techniques have produced connectivity maps of the brain, and computational modelling has elucidated the role of these networks in cognitive function. In this article, Sharp and colleagues review the effects of traumatic injury on the brain connectivity, and discuss how axonal damage affects the default mode network and saliency network to produce clinical symptoms.