胶束
纳米载体
体内
药物输送
临界胶束浓度
药品
聚合物
化学
毒品携带者
材料科学
水溶液
生物物理学
纳米技术
药理学
有机化学
医学
生物技术
生物
作者
Sung-Won Kim,Yunzhou Shi,Ji Young Kim,Kinam Park,Ji‐Xin Cheng
标识
DOI:10.1517/17425240903380446
摘要
Importance of the field: Spontaneously constructed from block copolymers in aqueous media, the polymer micelle has been extensively studied as a potential carrier of poorly water-soluble drugs, but cellular uptake pathways and stability of micelles in blood have not yet been clearly understood. An in-depth insight into the physical and biological behaviors of polymer micelles is necessitated for designing next-generation micelles.Areas covered in this review: This review suggests possible solutions to improve micellar drug loading capacity, scrutinizes the parameters influencing the micelle stability in blood, and also discusses the fate of micelles in cellular and in vivo environment, respectively. Direct and indirect evidences from the literatures mostly published after 90's were collected, analyzed and summarized.What the reader will gain: A critical analysis of micelle's stability in vivo and micelle-cell interaction is provided to highlight the key issues to be addressed to affirm that micelle can properly work as a drug carrier in clinical settings.Take home message: With a clear understanding of its behaviors in biological environment, the polymer micelle is a promising nanocarrier for chemotherapy.
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