Chemical constituents ofAntrodia camphoratasubmerged whole broth

Abstract One new compound, 10-hydroxy-γ-dodecalactone (1) and three natural new compounds, 11-hydroxy-γ-dodecalactone (2), 2-(2-hydroxyethyl)phenol (3) and 12-hydroxydodecanoic acid methyl ester (4), together with eight known compounds, ergostatrien-3β-ol, ergosterol peroxide, methyl (4-hydroxyphenyl)acetate, vanillin, 4-hydroxybenzaldehyde, hexadecanoic acid, 5-methoxymethylfuran-2-carbaldehyde and 5-hydroxymethylfuran-2-carbaldehyde, all were isolated from the submerged whole broth of Antrodia camphorata. The structures of 1 and 2 were principally elucidated by spectral evidence and the absolute configuration was elucidated by the modified Mosher's method. Keywords: Antrodia camphorata Submerged10-hydroxy-γ-dodecalactone11-hydroxy-γ-dodecalactone2-(2-hydroxyethyl)phenol12-hydroxydodecanoic acid methyl ester Acknowledgement This research was supported by the National Science Council of the Republic of China (NSC 91-2622-E-158-001-CC3).