发病机制
抗菌肽
炎症性肠病
抗菌剂
溃疡性结肠炎
免疫学
免疫系统
克罗恩病
先天免疫系统
炎症
疾病
结肠炎
医学
生物
微生物学
病理
作者
Jan-Michel Otte,Stefan Vordenbäumen
出处
期刊:Polymers
[MDPI AG]
日期:2011-11-16
卷期号:3 (4): 2010-2017
被引量:13
摘要
Inflammatory bowel diseases (IBD) are characterized by a chronic relapsing inflammation of the gastrointestinal mucosa. The etiology and pathogenesis of these disorders such as Crohn’s disease and ulcerative colitis are incompletely understood. Recently, antimicrobial peptides, which are expressed by leukocytes and epithelia, have been implicated in the pathogenesis of IBD. Antimicrobial peptides are pivotal for intestinal defense, shaping the composition of the luminal flora and contributing thereby to the maintenance of intestinal homeostasis. Apart from their antimicrobial activity affecting commensal bacteria, immunomodulatory properties of antimicrobial peptides have been identified, which link innate and adaptive immune response. There is increasing evidence that alterations in mucosal levels of these peptides contribute to IBD pathogenensis.
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