Wnt信号通路
转录因子
背景(考古学)
克鲁佩尔
药物发现
癌症
河马信号通路
生物
癌症研究
计算生物学
锌指
信号转导
生物信息学
细胞生物学
基因
遗传学
古生物学
作者
Yu Gao,Ye Ding,Haiying Chen,Haijun Chen,Jia Zhou
标识
DOI:10.2174/1568026615666150302105052
摘要
Krüppel-like factor 5 (KLF5) belongs to a family of zinc-finger-containing transcription factors which are involved in regulating expression of a wide range of genes, thereby affecting diverse cellular functions. The activities of KLF5 are regulated by multiple signaling pathways including Wnt, Ras, TGFβ, Hippo, Notch, retinoid acid receptor, and hormone receptors. The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context dependent. Accumulating evidence suggests that KLF5 represents a novel therapeutic target for cancer therapy. In this review, we discuss the potential biological functions of KLF5 associated with several key signaling pathways that are relevant to cancer as well as the involvement of KLF5 in various human cancers. We also describe the progress in the discovery and development of small molecules targeting KLF5 as potential therapeutics that may benefit cancer patients. The challenges and future research directions on the drug discovery of KLF5 ligands are also presented.
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