体内分布
体内
材料科学
生物相容性
胶体金
纳米颗粒
纳米技术
生物物理学
生物医学工程
医学
生物
冶金
生物技术
作者
Yanan Sun,Cai-Ding Wang,Xiuming Zhang,Lei Ren,Xin Tian
标识
DOI:10.1166/jnn.2011.3094
摘要
The toxicity and biodistribution in vivo of various morphologies of Au nanoparticles (AuNPs) were studied by using KM mice. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sphere-shaped AuNPs displayed the best biocompatibility, compared with rod- and cube-shaped of AuNPs, and rod-shaped AuNPs was more toxic than cube-shaped AuNPs. In vivo biodistribution study revealed all AuNPs were preferentially accumulated in organ of liver and spleen. The findings from this study thus revealed that the toxicity and biodistribution in vivo of AuNPs are shape dependent.
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