非对映体
不对称诱导
对映体
化学
对映选择合成
试剂
手性配体
产量(工程)
组合化学
催化作用
有机化学
材料科学
冶金
作者
Radha D. Pyarasani,John Amalraj,Leonardo S. Santos
标识
DOI:10.2174/15680266113139990151
摘要
Alkaloids are interesting groups of natural products with important biological properties, but naturally available alkaloids are insufficient for biological studies. Therefore, the demand for higher amounts of alkaloids made research community to synthesize alkaloids by innovative techniques. The importance of asymmetric reactions for scientific community to obtain enantiomerically pure compounds with good yield and diastereomeric excess (de) or enantiomeric excess (ee) by different strategies of asymmetric induction is emphasized in this review. In addition, importance have been given to discuss on biologically important alkaloids, their skeleton synthesis, intermediates and total synthesis with different strategies mainly based on chiral auxiliaries, chiral reagents and chiral metal ligand based catalysts. Keywords: Asymmetric synthesis, alkaloids, asymmetric induction, Chiral auxiliaries, Chiral catalyst, Chiral reagents.
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