纺神星
细胞外
瞬时受体电位通道
化学
钙
葡萄糖醛酸酶
TRPV6型
TRPC1型
内分泌学
生物化学
内科学
细胞生物学
生物物理学
肾
受体
生物
酶
医学
有机化学
作者
Qing Chang,Susan Hoefs,Jennifer Kemp,Catalin N. Topala,René J. M. Bindels,Joost G. J. Hoenderop
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-10-21
卷期号:310 (5747): 490-493
被引量:564
标识
DOI:10.1126/science.1114245
摘要
Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a β-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides.
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