作者
Hyun Ah Kim,Doo Ryeon Chung,Joon‐Sup Yeom,Hyun Kyun Ki,Hae Suk Cheong,Jun Seong Son,Jin Seo Lee,Soo Young Moon,Seung Soon Lee,Jeong–A Lee,Kyung Hwa Park,Suna Kang,Sook In Jung,Shin‐Woo Kim,Hyun Ha Chang,Seong Yeol Ryu,Ki Tae Kwon,Chisook Moon,Yu Mi Wi,Sang Taek Heo,Mi Kyong Joung,Cheol In Kang,Kyong Ran Peck,Jae Hoon Song
摘要
Although most Klebsiella pneumoniae liver abscesses have been reported to be monomicrobial, clinical outcomes have not been compared between antimicrobial therapy with and without anti-anaerobic coverage. A propensity score–matched cohort study was conducted using the 731 cases of K. pneumoniae liver abscess. Clinical outcomes were compared between a group discontinuing anti-anaerobic agents after K. pneumoniae identification and a group continuing. A total of 170 cases were matched at a 1:1 ratio using their propensity to discontinue anti-anaerobic agents. The McNemar's test showed no difference in mortality rates (1.8% for discontinuation versus 2.3% for continuation; P = 1.00) or relapse (1.8% versus 2.9%; P = 0.73) between groups. Early discontinuation of anti-anaerobic agents had no association with treatment failure by means of the generalized estimating equation model (odds ratio 0.48; P = 0.14) and the Kaplan–Meier method (P = 0.85) in matched groups. Early discontinuation of anti-anaerobic agents does not affect the clinical outcomes of patients with K. pneumoniae liver abscess.