急性呼吸窘迫综合征
医学
机械通风
肺炎
重症监护医学
镇静
呼吸衰竭
通风(建筑)
肺
呼吸窘迫
麻醉
呼吸机相关性肺炎
内科学
机械工程
工程类
作者
Liao Pinhu,Thomas Whitehead,Timothy W. Evans,Mark Griffiths
出处
期刊:The Lancet
[Elsevier]
日期:2003-01-01
卷期号:361 (9354): 332-340
被引量:368
标识
DOI:10.1016/s0140-6736(03)12329-x
摘要
Mechanical ventilation is indispensable in support of patients with respiratory failure who are critically ill. However, use of this technique has adverse effects, including increased risk of pneumonia, impaired cardiac performance, and difficulties associated with sedation and paralysis. Moreover, application of pressure to the lung, whether positive or negative, can cause damage known as ventilator-associated lung injury (VALI). Despite difficulties in distinguishing the effects of mechanical ventilation from those of the underlying disorder, VALI greatly assists patients with the most severe form of lung injury, acute respiratory distress syndrome (ARDS). Moreover, modification of mechanical ventilation so that VALI is kept to a minimum improves survival of patients with ARDS. Here, we outline the effects of mechanical ventilation on injured lungs and explore the underlying mechanisms.
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