体外
运动性
微生物学
真菌毒素
毒素
琼脂
酶
生物
化学
分子生物学
生物化学
食品科学
细菌
细胞生物学
遗传学
作者
Rabindra Roy,Gautam Bhattacharya,K. A. I. Siddiqui,Rupak K. Bhadra
标识
DOI:10.1016/0006-291x(90)91672-f
摘要
Inclusion of phaseolinone, a newly described mycotoxin, at 20 μg per ml in a solid culture medium (blood agar overlay) and at 50 μg per ml in a liquid culture (medium 199) inhibited the growth of L. donovani promastigotes. About 90% of the motile promastigotes lost motility after exposure to 50 μg per ml of phaseolinone for 6–7 h and here 3-day-old culture was more sensitive than 7-day-old culture. In an invitro assay, DNA dependent RNA polymerase activity of 3-day-old promastigotes was considerably inhibited in the presence of this toxin. Therefore, this key enzyme was suggested to be one of the sites of action of phaseolinone.
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