聚电解质
电喷雾
水溶液
化学工程
材料科学
壳聚糖
色谱法
化学
聚合物
质谱法
有机化学
复合材料
工程类
作者
Yu Fukui,Tatsuo Maruyama,Yuko Iwamatsu,Akihiro Fujii,Tsutomu Tanaka,Yoshikage Ohmukai,Hideto Matsuyama
标识
DOI:10.1016/j.colsurfa.2010.08.039
摘要
The preparation of polyelectrolyte microcapsules by electrospray was investigated. When a polyanionic or polycationic aqueous solution was electrosprayed into an aqueous solution containing a polyelectrolyte with the opposite charge, a spherical interface consisting of a polyelectrolyte complex was formed by electrostatic interaction to produce a microcapsule. Alginate/chitosan microcapsules (∼100 μm) were successfully produced with a narrow diameter distribution (coefficient of variation 4.4%). The diameters of microcapsules were controlled in the range of 80–230 μm by varying the operating conditions, such as feed rate, working voltage, the distance from needle-to-collector, needle diameter and polyelectrolyte concentrations. We also succeeded in the encapsulation of protein, dextran and a polymeric microsphere within the polyelectrolyte microcapsules with high encapsulation efficiencies (more than 99%). The study of yeast encapsulation reveals that the electrospray technique can encapsulate a physiologically active substrate in the polyelectrolyte microcapsule and maintain its activity.
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