超临界流体
蒸发
气溶胶
混合(物理)
材料科学
纳米颗粒
粒子(生态学)
降水
化学工程
体积流量
喷射(流体)
沸点
粒径
纳米技术
化学
热力学
气象学
有机化学
物理
地质学
工程类
量子力学
海洋学
作者
Hak‐Kim Chan,Philip Chi Lip Kwok
标识
DOI:10.1016/j.addr.2011.03.011
摘要
This review focuses on bottom-up processes such as precipitation (or crystallisation) and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications. Suitable precipitation techniques involve the use of high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, and ultrasonic waves. Droplet evaporation methods are spray-based, including nanospray drying, aerosol flow reactor method, spraying of low-boiling point solvent under ambient conditions and electrospraying of low-electrical conducting solutions. A key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics through evaporation rate of the droplets or mixing rate during precipitation.
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