JAK-STAT信号通路
STAT蛋白
细胞生物学
生物
信号转导
斯达
激活剂(遗传学)
转录因子
基因
贾纳斯激酶
遗传学
车站3
受体酪氨酸激酶
作者
David S. Aaronson,Curt M. Horvath
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2002-05-31
卷期号:296 (5573): 1653-1655
被引量:1297
标识
DOI:10.1126/science.1071545
摘要
The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.
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