3-Hz brain stimulation interferes with various aspects of the kindling effect

These exploratory experiments investigated the effect of 3-Hz brain stimulation on behavior induced by 60-Hz brain stimulation when the former was presented simultaneously with, or following, the latter. In the simultaneous case, 3-Hz stimulation to one amygdala and 60 Hz to the other produced a slower kindling rate than did bilateral stimulation with 60 Hz. When 3-Hz stimulation followed six convulsion trials of 60-Hz stimulation, there was no effect on the convulsive tendency; however, with rats in which the convulsive pattern was relatively stable and 48 or more convulsive trials were followed by 24 trials of 3-Hz stimulation at double intensity or 36 trials at the same intensity as previous 60-Hz stimulation, a reversal effect was observed, that is, a return to nonconvulsive behavior.