平滑
刺猬
串扰
信号转导
刺猬信号通路
生物
转录因子
细胞生物学
Hes3信号轴
细胞信号
背景(考古学)
遗传学
Notch信号通路
基因
物理
古生物学
光学
作者
David J. Robbins,Dennis Liang Fei,Natalia A. Riobó
出处
期刊:Science Signaling
[American Association for the Advancement of Science (AAAS)]
日期:2012-10-16
卷期号:5 (246)
被引量:361
标识
DOI:10.1126/scisignal.2002906
摘要
Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic and adult structures, and disruption of Hh signaling pathways results in various human diseases. Here, we provide a comprehensive review of the signaling pathways regulated by Hh, consolidating data from a diverse array of organisms in a variety of scientific disciplines. Similar to the elucidation of many other signaling pathways, our knowledge of Hh signaling developed in a sequential manner centered on its earliest discoveries. Thus, our knowledge of Hh signaling has for the most part focused on elucidating the mechanism by which Hh regulates the Gli family of transcription factors, the so-called "canonical" Hh signaling pathway. However, in the past few years, numerous studies have shown that Hh proteins can also signal through Gli-independent mechanisms collectively referred to as "noncanonical" signaling pathways. Noncanonical Hh signaling is itself subdivided into two distinct signaling modules: (i) those not requiring Smoothened (Smo) and (ii) those downstream of Smo that do not require Gli transcription factors. Thus, Hh signaling is now proposed to occur through a variety of distinct context-dependent signaling modules that have the ability to crosstalk with one another to form an interacting, dynamic Hh signaling network.
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