恶性疟原虫
传统医学
加勒比
药用植物
疟疾
体外
生物
生药学
植物
医学
生物活性
生物化学
免疫学
作者
Gurpur Praveen Bhat,Namita Surolia
出处
期刊:American Journal of Tropical Medicine and Hygiene
[American Society of Tropical Medicine and Hygiene]
日期:2001-10-01
卷期号:65 (4): 304-308
被引量:107
标识
DOI:10.4269/ajtmh.2001.65.304
摘要
In an attempt to search for new antimalarial drugs, we studied plants used by traditional healers of southwest India to treat malaria. Aqueous and organic solvent extracts obtained from specific parts of the plants Swertia chirata, Carica papaya, and Citrus sinensis were tested on malaria strain Plasmodium falciparum FCK 2 in vitro. The temperatures of extraction were the same as that used by the traditional healers in their plant preparations. Visual evaluation of the antimalarial activity of the plant extracts on thin blood smears was followed by quantification of the activity by use of [35S]-methionine incorporation into parasite proteins to determine the value that inhibits 50% (IC50). Among the 3 plants tested, 2 had significant inhibitory effect on P. falciparum in vitro.
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